Conformational Transitions in Protein-Protein Association: Binding of Fasciculin-2 to Acetylcholinesterase
نویسندگان
چکیده
منابع مشابه
Conformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesterase.
The neurotoxin fasciculin-2 (FAS2) is a picomolar inhibitor of synaptic acetylcholinesterase (AChE). The dynamics of binding between FAS2 and AChE is influenced by conformational fluctuations both before and after protein encounter. Submicrosecond molecular dynamics trajectories of apo forms of fasciculin, corresponding to different conformational substates, are reported here with reference to ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2006
ISSN: 0006-3495
DOI: 10.1529/biophysj.105.075564